Hydrogen Bonding Directed Intermolecular Cope-Type Hydroamination of Alkenes
收藏NIAID Data Ecosystem2026-03-07 收录
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Intermolecular hydroamination of unactivated alkenes represents a significant synthetic challenge. An efficient Cope-type hydroamination is achieved under mild conditions for reactions of N-alkylhydroxylamines with allylic amines, using hydrogen bonding to achieve increased reactivity and high regioselectivity. This approach provides a number of highly functionalized vicinal diamine motifs as Markovnikov addition products.
创建时间：
2012-10-05
