Model of Ehrlich-Hunt.

BackgroundThis study aimed to evaluate the effect of tannic acid on colonic anastomosis in a sepsis model induced by cecal abrasion.Materials and methodsThirty Sprague-Dawley rats were used. The animals were randomly divided into three groups of ten: Group 1 (n:10): Colonic anastomosis + 0.9% isotonic NaCl. Group 2 (n:10): Cecal ligation and puncture + Colonic anastomosis + 0.9% isotonic NaCl. Group 3 (n:10): Cecal ligation and puncture + Colonic anastomosis + Tannic Acid group. The rats were sacrificed on the fifth postoperative day, and the resected colon segments, bursting pressure, hydroxyproline levels, and histopathologic features of the anastomosis were evaluated.ResultsThe bursting pressure value was statistically significantly higher in Group 3, where tannic acid was administered (p ConclusionThis experimental study revealed that the use of tannic acid during anastomosis has a positive effect on wound healing, acting through higher colonic anastomotic bursting pressures and higher tissue hydroxyproline levels.