Screening of lncRNAs involved in cancer cell evasion of extrinsic and intrinsic apoptotic pathways. Screening of lncRNAs involved in cancer cell evasion of extrinsic and intrinsic apoptotic pathways

We generated ME4405 TRAIL-selected (TRAIL.S) and ME4405 UMI-77-selected (UMI-77.S) cell sub-lines that were resistant to TRAIL and the Mcl-1 inhibitor UMI-77, respectively, after long-term exposure to drug treatment. By performing RNA-sequencing analysis, we found that 37 upregulated lncRNAs in common between TRAIL.S and UMI-77.S cells, suggesting these lncRNAs may function in both extrinsic and intrinsic apoptotic pathways. Overall design: Examination of functional lncRNA(s) responsible for cancer cells evading apoptosis.