Interleukin enhancer-binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma

This study aimed to understand the role of ILF2 upregulation in metastatic melanoma cutaneous progression and DNA damage response. The goal of RPPA analysis was to determine the protein expression profiles in DP-0574 and IM-0223 melanoma cell lines with ILF2 overexpression (ILF2-OV) or control empty vector (EV). By analysis of RPPA in both metastatic melanoma cell lines, we found that ILF2-OV controls significantly increased RAD50 expression. RPPA profiles for DP-0574 and IM-0223 cell lines with ILF2 overexpression (ILF2-OV) or control empty vector (EV) were generated in triplicates.