Genome-Wide Identification of Genes Required During Bloodstream Infection in Multi-Drug Resistant Acinetobacter baumannii.

Acinetobacter baumannii is a leading nosocomial, multidrug resistant pathogen. A. baumannii infects a wide range of anatomic sites including the respiratory tract, the bloodstream, the urinary tract, the meninges, etc. Furthermore, the mortality rate associated to A. baumannii infections is about 43%. Despite its clinical importance, relatively little is known about the molecular basis of A. baumannii pathogenicity. To better understand A. baumannii virulence, a combination of a transposon-sequencing (TraDIS) screen and the neutropenic mouse model of bacteremia was used to identify the full set of fitness genes required during bloodstream infection.