Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B

Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B Descriptor: (7R)-8-cyclopentyl-2-(3,5-dichloro-4-hydroxyanilino)-5-methyl-7-[(pyridin-2-yl)methyl]-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION Authors: He, Z, Ha, Y. Deposit date: 2026-02-13 Release date: 2026-04-29 Last modified: 2026-06-10 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B. Acta Crystallogr D Struct Biol, 82, 2026