Crystal structure of KSP in complex with inhibitor 30
收藏Protein Data Bank Japan2023-08-30 更新2026-03-21 收录
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Crystal structure of KSP in complex with inhibitor 30 Descriptor: (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... Authors: Yan, Y. Deposit date: 2008-03-13 Release date: 2008-07-01 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. J.Med.Chem., 51, 2008
创建时间：
2008-03-13
