Spatial learning with a minislab in the dorsal hippocampus.
收藏PubMed Central1995-10-10 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC40869/
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资源简介：
We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support spatial learning in a water maze, provided it was at the septal (dorsal) pole of the hippocampus. Lesions of the septal pole, leaving 60% of the hippocampi intact, caused a learning deficit, although normal electrophysiological responses, synaptic plasticity, and preserved acetylcholinesterase staining argue for adequate function of the remaining tissue. Thus, with an otherwise normal brain, hippocampal-dependent spatial learning only requires a minislab of dorsal hippocampal tissue. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-10-10
