Reported hypoglycaemic episodes in patients with type-1 diabetes during one year of treatment with metformin or placebo.

Data are included for at total of 99 patients (one patient, in the placebo group, out of a total of 100 randomized patients, had missing data on hypoglycaemia).aNot compared statistically due to equal proportions of patients in treatment groups.bp compared to enrolment (Table 2).cLevels of circulating glucose were captured periodically by patients estimating average levels of blood/plasma glucose during hypoglycaemic events. The calibration (plasma or whole blood glucose) of hand held devices was not registrated, nor was devices calibrated at enrolment. Hence, data represent non-standardized plasma and/or blood glucose measurements. Not all patients had available glucose measurements during events. The total number of patients with available measurement was: Minor hypoglycaemia: metformin: n = 47; placebo: n = 49; Major hypoglycaemia: metformin: n = 11; placebo: n = 8.dp = 0.011 and p = 0.209 compared to enrolment for metformin and placebo, respectively (Table 2).ep = 0.049888455.