DNA Damage Response of Myotis lucifugus

The goal is to understand how genetic variation in Myotis lucifugus leads to differences in the DNA damage response between individuals. More specifically, differences in either alleles or structural variation can lead to differences in the speed and magnitude of the response to DNA damage, with implications for the possible outcomes of the damage. Understanding how these variants influence the DNA damage response can then be leveraged to improve our understanding of how genetic variants in humans or within a tumor can change in response to DNA damage accumulated passively over time, or actively in response to treatment.