Data from: Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study

Objective: The purpose of this study was to determine the relationship
between serum γ-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave
velocity (baPWV) as an indicator for atherosclerosis in Japanese men and
women after adjusting for fatty liver. Design: A cross-sectional study.
Setting: A health check-up centre in Japan. Participants: 912 Japanese men
and women aged 24–84 years recruited from people who received a medical
health check-up programme with a standardised questionnaire and an
automatic waveform analyser to measure baPWV. Main outcome measures: We
measured serum GGT concentrations and baPWV. Fatty liver was diagnosed by
standardised criteria using abdominal ultrasonography. The postmenopausal
state was defined as beginning 1 year after the cessation of menses.
Results: In women, log2 GGT was positively associated with baPWV (β=0.11,
95% CI 0.02 to 0.19, p<0.05), independent of age, body mass index,
systolic blood pressure, fasting plasma glucose, triglycerides, estimated
glomerular filtration rate, fatty liver, menopausal state and parameters
of lifestyles. However, in men, the positive association of log2 GGT with
baPWV was not significant (β=−0.04, 95% CI −0.10 to 0.03, p=0.28) in
multivariable linear regression analyses. Conclusions: The serum GGT level
was associated with baPWV, independently of covariates including fatty
liver or menopausal state just in women, but not in men.