Fig3H. Acetylcholine (Ach)-induced endothelium-dependent vasodilation was impaired in aortas from aged (18-month old) mice compared to the young (3-month old) mice, and NOXA1ds (30 µmol/l, 1hr) ameliorated endothelial dysfunction in aortas from aged mice
We used Tandem Mass Tags (TMT) 11-plex coupled to 2D-LC-MS/MS to profile EDL muscles from WT and SOD1 G37R mice at presymptomatic (P380) and symptomatic (P480) stages. This strategy not only