Crystal structure of the human PAD2 protein bound to small molecule

Crystal structure of the human PAD2 protein bound to small molecule Descriptor: (1P)-N~3'~-[(2S)-3-cyclohexyl-1-(methylamino)-1-oxopropan-2-yl]-N~3~,N~3~-diethyl-4-fluoro-5'-{[4-(4-phenylbutyl)piperazin-1-yl]methyl}[1,1'-biphenyl]-3,3'-dicarboxamide, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... Authors: Byrnes, L.J, Vajdos, F. Deposit date: 2024-04-01 Release date: 2024-10-09 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Discovery, Characterization, and Structure of a Cell Active PAD2 Inhibitor Acting through a Novel Allosteric Mechanism. Acs Chem.Biol., 19, 2024