Molecular Genetics of Histiocytic Sarcoma

This is a comprehensive genomic analysis of a rare set of histiocytic sarcomas from the consult service of the Hematopathology section of the Laboratory of Pathology, NCI, NIH. The study identifies two distinct groupings of these tumors based on the site of disease, their mutational spectrum, and proliferation signature.]]> All archived consult cases with a confirmed pathologic diagnosis of histiocytic sarcoma were eligible for this study. Cases with prior or concordant history/diagnosis of a lymphoproliferative disease were excluded from the study.]]> This is a new study of the genomics of histiocytic sarcoma and includes only de novo primary cases. It is primarily a tumor only study, and bioinformatic approaches have been used to identify likely somatic mutations from the sequencing data. Follow up studies cases associated with lymphoproliferative disorders are planned.]]>