Ru(II)-Catalyzed C–H Hydroxyalkylation and Mitsunobu Cyclization of <i>N</i>‑Aryl Phthalazinones
收藏NIAID Data Ecosystem2026-03-11 收录
数据链接：
官方服务：
资源简介：
Ruthenium(II)-catalyzed C(sp2)–H functionalization of N-aryl phthalazinones with a range of aldehydes and activated ketone is described. Initial formation of hydroxyalkylated phthalazinones and subsequent Mitsunobu cyclization provided facile access to biologically relevant indazolophthalazinones. The utility of this method is highlighted by synthetic transformations into a series of potentially bioactive scaffolds.
创建时间：
2020-01-06
