Consecutive Cycloaddition/S_NAr/Reduction/Cyclization/Oxidation Sequences: A Copper-Catalyzed Multicomponent Synthesis of Fused N‑Heterocycles

A highly efficient multicomponent domino protocol has been developed for the synthesis of 5-phenyl-[1,2,3]­triazolo­[1,5-c]­quinazolines from simple and readily available (E)-1-bromo-2-(2-nitrovinyl)­benzenes, aldehydes, and sodium azide. This elegant domino process involved consecutive [3 + 2] cycloaddition, copper-catalyzed SNAr, reduction, cyclization, and oxidation sequences. Notably, sodium azide acted as a dual nitrogen source in the construction of this novel fused N-heterocycle.