Simultaneous inhibition of SIRT3 and cholesterol homeostasis targets AML stem cells by perturbing fatty acid ß-oxidation and inducing lipotoxicity

To invesetigate the transcriptional changes as a result of SIRT3 perturbation in leukemic stem cells and AML blasts Overall design: Leukemic stem cells and blasts enriched from patient samples were treated with inhibitor or control and collected for RNA sequencing.