EGFR kinase domain in complex with a covalent aminobenzimidazole inhibitor.
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EGFR kinase domain in complex with a covalent aminobenzimidazole inhibitor. Descriptor: Epidermal growth factor receptor, ~{N}-[7-methyl-1-[(3~{R})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide Authors: DiDonato, M, Spraggon, G. Deposit date: 2015-12-16 Release date: 2016-07-27 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.651 Å) Cite: Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers. J.Med.Chem., 59, 2016
创建时间：
2015-12-16
