Supplementary Material for: Chemical Leukoderma or Vitiligo – Where do we draw the line? : A Case Report

Introduction: Vitiligo is a skin depigmenting disorder influenced by both genetic and environmental factors. In contrast, chemical leukoderma (CL) is an acquired form of depigmentation caused by repeated exposure to specific chemical compounds. There is growing evidence of a similar pathogenesis in both entities, however in some cases it remains unclear. Case Presentation: We present a case of a 26-year-old female who developed widespread depigmentation after using "lightening creams" containing Monobenzyl Ether Hydroquinone purchased online. The lesions displayed various tones of skin color, including discrete macules and confluent patches with defined borders. Her history of chemical exposure and subsequent depigmentation strongly supports the diagnosis of CL. Conclusion: We aim to share this interesting case of widespread CL, review of pathogenesis and highlight the importance of awareness about commercially distributed products, particularly those sold online.