H3K27me3 maintains the transcription program during epigenetic reprogramming in the mouse germ line [RNA-seq]
收藏Alliance of Genome Resources2026-08-01 收录
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To investigate the role of EZH2 in transcription regulation in mouse primordial germ cells, we isolated Ctrl and Ezh2 CKO male and female PGCs at E13.5. Our data demonstrates that EZH2-mediated H3K27me3 is required for regulating the expression of meiotic genes in the female germ cells. Furthermore, RNA-seq analysis shows that EZH2 is essential for transcriptional repression of retrotransposons. Expression profiles of Ctrl and Ezh2 CKO male and female mouse primordial germ cells at E13.5.
