The Asthma Universe: Mechanistic Network Dataset of Human Asthma Pathophysiology

This dataset accompanies a scoping review of human asthma pathophysiology that systematically mapped the recent review literature (2021–2026) into a structured mechanistic network. It contains all data underlying the published synthesis, in fully reusable formats. Contents: Asthma_Network_Database.xlsx — Master database with four linked sheets: Nodes (entities with role, biological level, asthma subtype attribution, priority classification, and source attribution), Connections (narrative pathways extracted from each source), Uncertain Findings (624 entries reflecting contested or context-dependent reports), and Summary (descriptive statistics and controlled vocabularies). EDGES_FINAL_NETWORK.xlsx — Final edge list of the network: 1,632 edges (1,558 unidirectional, 74 bidirectional) connecting 265 nodes, with explicit attributes for direction, functional role (pathogenic, protective, mixed, therapeutic), asthma subtype, and source citation. Asthma_Therapies_Database.xlsx — Companion catalogue of 767 therapeutic entries (inhaled corticosteroids, bronchodilators, biologics, emerging non-T2 therapies, non-pharmacological interventions, comorbidity-directed treatments, treatable-traits approaches), each linked to one or more network nodes. asthma_network.html — Interactive D3.js-based network visualization with on-demand filtering by cluster, role, and asthma subtype. Supplementary_Table_S1_PubMed_Queries.xlsx — Full list of seventeen PubMed/Scopus/WoS/Embase/Cochrane queries with record counts. Supplementary_Table_S2_Non_Retrieved.xlsx — 92 sources sought but not retrievable in full text, with PubMed identifiers. Supplementary_Table_S3_Excluded_Full_Text.xlsx — Full-text exclusions aggregated by reason. PRISMA-ScR_Checklist.docx — Completed PRISMA Extension for Scoping Reviews checklist. PRISMA_Flow_Diagram.pdf — PRISMA 2020 flow diagram of source selection. The dataset is released under CC BY 4.0 to enable formal network-medicine analyses, replication, and extension to other multi-factorial chronic diseases. All data derive from human-evidence sources; animal and cell-line evidence was systematically excluded from extraction.