A pan-family screen of Nuclear Receptors in immunocytes reveals ligand-dependent inflammasome control [RNA-seq 2]

We performed RNAseq profiling of sorted LYVE1+CD206+ MFs from WT, RAR? mutant and RXRa mutant converting macrophages (Conv.MF). Overall design: RNA-seq was performed on purified Conv.MFs sorted from “Rainbow-CRISPR” mice 25 days after reconstitution, mutant cells and WT cells were matched from the same BMC mouse. Biological replicates were obtained for each NR ablation.