Transcriptomic analysis of microglia from 7 week Npc1 disease mouse model treated or not with 4000mg.kg-1 HPBCD

the study aims to describe the modifications occurring the microglia isolated from NPC1 disease mouse model using a transcriptomic and phenotypic approach. The analysis is also performed on animal treated with the reference drug HPBCD, currently under clinical trial in human. FACS isolated cell from Npc1 KO and WT mice were harvested from 7-week-old animals treated with HPBCD (n=3/genotype) or vehicle (n=3/ genotype) or no treatment (n=5/ genotype). Transcriptome was analyzed for modified signaling pathway further validated by additional experiments.