Crystal structure of tubulin in complex with D-DM1-SMe

Crystal structure of tubulin in complex with D-DM1-SMe Descriptor: (10E,12E)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylsulfinothioyl)propanoyl)-D-alaninate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... Authors: Wang, Y, Li, W. Deposit date: 2021-02-15 Release date: 2021-07-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.597 Å) Cite: C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids. Biochem.Biophys.Res.Commun., 566, 2021