Consequences of the perivascular niche remodeling for tumoricidal T-cell trafficking into metastasis of ovarian cancer [scRNA-seq]

We investigated the mechanisms by which inflammatory responses generated by tumor-specific T cells delivered to ovarian tumor-bearing mice alone or after oncolytic vaccinia virus-driven immunogenic cancer cell death affect antitumor efficacy using scRNA-seq. Tumor draining lymph nodes in MOVCAR 5009 tumor-bearing SCID mice were analyzed using 10 Genomics single cell RNASeq platfomr 10 days after the treatment.