Effect of Dahuang Huanglian Xiexin Decoction (XXD) on the gut microbiome of dysbiosis mice

Dahuang Huanglian Xiexin Decoction (XXD), derived from Zhang Zhongjing's Treatise on Typhoid Fever, has a long history of medicinal use and is widely used for digestive system diseases. It is mainly composed of three natural medicines, including Dahuang (Rheum palmatum L.), Huanglian (Coptis chinensis Franch.), and Huangqin (Scutellaria baicalensis Georgi). Modern pharmacological research shows that the active ingredients of XXD can have a positive effect on gut microbiome regulatory effect.In this study, we found that XXD could improve the richness and diversity of gut microbiome in dysbiosis mice and had a good regulatory effect on dysbiosis.