Comparison of bone mineral content (BMC) and density (BMD) of the mid-point femurs between WT and <i>igf1</i> KO mice during calcium depletion or repletion.

Data are shown as Mean ± SEM. # The control group are mice receiving normal calcium-containing diet throughout. a P<0.001; b P<0.01; c P<0.05; when compared to corresponding WT littermates. P = N.S., not significant, when P>0.05. * Measured at metaphysis area immediately from secondary spongiosia. Comparison of bone mineral content (BMC) and density (BMD) of the mid-point femurs between WT and igf1 KO mice during calcium depletion or repletion.