BackgroundTissue covalently closed circular DNA (cccDNA) can reflect the activity of HBV replication. However, it is impractical to assess intrahepatic cccDNA in every outpatient. Serum pregenome RNA
Background Chronic hepatitis B (CHB) is prevalent worldwide. The infectious agent, hepatitis B virus (HBV) replicates rapidly and is error-prone, leading to rapid evolution of closely related but not
* Annual monitoring costs include ALT and HBV DNA tests.± See Levy et al. [50] for age-specific utilities.Annual base case cost and utility estimates (2014).
