Gene associations and colocalization with eQTLs.

We performed COLOC to test colocalization between HCHS/SoL GWAS and eQTL data in our transcriptomic models (44 GTEx, 5 MESA). We found 40/59 of significant (P < 3.61×10−8) PrediXcan associations had significant probability (P4 > 0.5) for colocalization, indicating that the variants may be acting through gene regulation to affect the phenotypes. P3 > 0.5 indicates independence between GWAS and eQTL signals. Full results are available at https://github.com/WheelerLab/px_his_chol.