Whole transcriptome analysis of the antidepressant baicalin in chronic unpredictable mild stress mice

We identified 371 differentially genes including 216 up-regulated and 155 down-regulated genes by calculating the gene FPKM in each sample. The clustering analysis showed that differentially genes were separated into two distinguishing branches. Gene ontology analysis suggested that differentially genes mainly involved regulation of transcription (DNA-templated), transcription (DNA-templated), and protein phosphorylation in biological process, DNA binding, ATP binding and transferase activity in molecular function, and synapse, postsynaptic density, postsynaptic membrane in cellular component. Among these results indicated that the effect of baicalin may involve synapse function and ATP regulation. C57BL/6N mice was exposed to chronic unpredictable mild stress, and divided to CUMS group that was given saline, baicalin group that was treatment with baicalin (20 mg/kg).