Genome-wide analysis of gene expression modulated by anthracycline-based chemotherapy CHOEP in malignant T-cell lines. Genome-wide analysis of gene expression modulated by anthracycline-based chemotherapy CHOEP in malignant T-cell lines

Analysis of gene expression modulations induced by CHOEP treatment in malignant T-cell lines. The hypothesis tested in the present study was that the different sensitivity of malignant T-cell lines to CHOEP exposure can be explained by differentially expressed genes and pathways. Results provide evidence that a number of genes are up- or down-regulated in response to CHOEP, suggesting the activation of pro-survival druggable pathways activated by chemotherapy. Overall design: Total RNA obtained from cell lines treated with CHOEP for 24 hours compared to untreated control cells. For each cell line three biological replicates per experimental condition were analyzed.