This study contains pain data and tissue samples from patients with knee osteoarthritis, including questionnaires (EQ5D, OKS, VAS), synovitis scores, and transcriptomic data of synovial tissues from p

DataCite Commons2024-11-07 更新40

Identification of Cannabigerol-Derived Dual CB 2 Receptor Agonists and TRPM8 Antagonists with Anti-Inflammatory and Analgesic Activities

镇痛药物开发

CB2受体

Emerging evidence suggests that compounds possessing both CB2 receptor (CB2R) agonist and TRPM8 antagonist activities may offer effective pain relief while minimizing the severe side effects commonly

NIAID Data Ecosystem20

Microarray Analyses of the Dorsal Root Ganglia Support a Role for Innate Neuro-Immune Pathways in Persistent Pain in Experimental Osteoarthritis. Microarray Analyses of the Dorsal Root Ganglia Support a Role for Innate Neuro-Immune Pathways in Persistent Pain in Experimental Osteoarthritis

关节炎疼痛机制

神经免疫交互作用

Objective – Following destabilization of the medial meniscus (DMM), mice develop experimental osteoarthritis (OA) and associated pain behaviors that are dependent on the stage of disease. We aimed to

NIAID Data Ecosystem50

Table8_Osteocytes contribute to sex-specific differences in osteoarthritic pain.csv

关节炎疼痛机制

性别差异研究

Osteoarthritic (OA) pain affects 18% of females and 9.6% of males aged over 60 worldwide, with 62% of all OA patients being women. The molecular drivers of sex-based differences in OA are unknown. Bon

NIAID Data Ecosystem20

File S1 - Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

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