Variables independently associated with admission biomarkers reflecting endothelial glycocalyx and cell activation and/or damage, and endothelial cell junction function (syndecan-1, sE-selectin, thrombomodulin and sVE-cadherin, respectively) by backwards multivariate linear regression analysis in 163 patients admitted to a tertiary university hospital after out-of-hospital cardiac arrest.

Regression coefficients (β) with 95% confidence intervals (95%CI), p-values and adjusted R2 are displayed, with p-values <0.05 shown in bold. Predicted changes in syndecan-1 (ng/ml, reflecting glycocalyx damage), sE-selectin (ng/ml, reflecting endothelial activation), Thrombomodulin (ng/ml, reflecting endothelial cell injury) and sVE-cadherin (ng/ml, reflecting endothelial junction disruption) associated with one unit increase in the explanatory variables (age (1 year older), BMI, number of defibrillations (NS all over, data not shown), time from OHCA to ROSC (min), pH, STEMI (yes), p-adrenaline and p-noradrenaline (10-fold higher, NS all over, data not shown), syndecan-1, thrombomodulin, sE-selectin and VE-cadherin (all 2-fold higher). NS, non-significant. NA, non-applicable.
Variables independently associated with admission biomarkers reflecting endothelial glycocalyx and cell activation and/or damage, and endothelial cell junction function (syndecan-1, sE-selectin, thrombomodulin and sVE-cadherin, respectively) by backwards multivariate linear regression analysis in 163 patients admitted to a tertiary university hospital after out-of-hospital cardiac arrest.