Cryo-EM structure of the A946T MDA5-dsRNA filament

Cryo-EM structure of the A946T MDA5-dsRNA filament Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3'), RNA (5'-R(P*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*GP*AP*C)-3'), ... Authors: Singh, R, Herrero del Valle, A, Modis, Y. Deposit date: 2024-04-25 Release date: 2025-02-26 Last modified: 2025-06-18 Method: ELECTRON MICROSCOPY (3.97 Å) Cite: Molecular basis of autoimmune disease protection by MDA5 variants. Cell Rep, 44, 2025