GABA, 2’MeO6MF, etomidate and propofol concentration-response curve parameters at β3γ2L (1:15), (1:50) and (1:100) GABAARs derived from curve-fitting procedures.
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a The total amount of mRNA injected per oocyte was adjusted to be approximately 5 ng for each ratio.b Data of 1:15 ratio were better fitted to a monophasic model. Data of 1:50 and 1:100 ratios were significantly better fitter to a biphasic model (p F test). Concentration-response curves are shown in Fig 4F.c Current amplitude elicited by 30 mM GABA.d 300 μM 2’MeO6MF-elicited current normalised against 3 mM GABA response.e 30 μM (for 1:15) and 300 μM (for 1:50 and 1:100) etomidate-elicited current normalised against 3 mM GABA response.f 300 μM etomidate-elicited current normalised against 3 mM GABA response.g N.D. = not determined.h 300 μM propofol-elicited current normalised against 3 mM GABA response.GABA, 2’MeO6MF, etomidate and propofol concentration-response curve parameters at β3γ2L (1:15), (1:50) and (1:100) GABAARs derived from curve-fitting procedures.
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2015-12-03



