Supplementary Material for: Efficacy of a non-pharmacological intervention in seasonal allergic rhinitis symptoms

Background – Patients suffering from allergic rhinitis seek for several therapeutic symptomatic options, including non-conventional treatments, to control their symptoms.
Objectives – Through the present proof of concept study, we prospectively investigated the potential role of Puressentiel® nasal protection spray (SNPA) in patients suffering from cypress pollen allergic rhinitis.
Methods – In 15 adults, we performed two nasal provocation tests, with a cypress pollen extract, with a 15-days interval, with and without previous randomized administration of SNPA, and evaluated a nasal symptom score, the nasal inspiratory peak flow, and the concentration of inflammatory cytokines in the nasal lavage after the procedures.
Results – Comparing results in patients challenged with and without the SNPA spray before the nasal challenge, we found a 57% mean decrease in symptoms, and a 62% average difference in inspiratory peak flow, after the use of the spray.
Conclusions – Puressentiel® SNPA is effective in reducing nasal symptoms, as assessed by nasal symptoms score and nasal inspiratory peak flow, and could be a valid natural non-pharmacological option in patients suffering from allergic rhinitis.