NetworKIN analysis of VUS affecting biologically uncharacterized phosphorylation sites in BRCA1 and BRCA2.

In bold are BRCA1 mutations that fall within an experimentally identified but biologically uncharacterized phosphorylation site. aThe position and change at the amino acids specified by the missense variant is as reported in the BIC database. bThe nucleotide change conforms to the HGVS nomenclature. cSNP IDs correspond to the dbSNP database [73] SNP identifiers. dFrequency represents the number of times reported in the BIC database. eThe ten-residue long biologically uncharacterized kinase recognition motifs are shown. The biologically uncharacterized Serine (S), and threonine (T) residues shown to be phosphorylated by NetworKIN are underlined. * Sites that retained a score but was considered to be “abolished” due to score falling below 5 with the presence of the VUS.