Transcriptomic alteration of bone-related cells in aged mice after long-term high fat diet (HFD) feeding

Aging is associated with osteoporosis and remodeling of bone marrow microenvironment, skewing hematopoiesis. Obesity may accelerate aging process. We use bulk-RNA sequencing to measure the transcriptomic changes of bone cells caused by long-term HFD feeding in aged mice, which mainly includes osteocytes and other bone marrow stromal cells. mRNA profiles of cortical bone from 18-month old male C57BL/6J mice under 12-month chewing diet (CD) or HFD feeding.