Influenza C virus co-infections, clinical symptoms, and genomics from pediatric acute respiratory cases, Shandong, China

Five pediatric acute respiratory cases diagnosed with influenza C virus (ICV) infection were reported in Shandong, China and exhibited a wide spectrum of symptoms including fever, headache, cough, expectoration, throat congestion, vomiting, or diarrhea. Co-infection with other respiratory pathogenic viruses were also detected in four of these cases. Two genomes of ICV were obtained, and clustered in the S1-sublineage of C/Sao Paulo/378/82 (SP82) indicating genetically diverse ICV strains have been circulating undetected in China.