High throughput sequencing analyzes small RNA profile alteration in the exosomes from lung cancer patients and healthy controls. High throughput sequencing analyzes small RNA profile alteration in the exosomes from lung cancer patients and healthy controls

Purpose: The goals of this study are to compare the small RNA expression profiles in the peripheral exosomes and try to find biomarkers for early diagnosis of lung adenocarcinoma Methods: Exosome was extracted from peripherial blood samples from 5 patients with lung adenocarcinoma and 5 healthy controls. RNA was extracted and microRNA profile was analyzed by high througput sequencing. Results: The expression of 5 microRNAs was found significantly altered in patients with lung adenocarcinoma Overall design: Examination of peripheral blood exosome microRNAs from 5 patients with lung adenocarcinoma and 5 healthy controls