Transcriptomic analysis of head and neck cancer stable cell lines [RNA-seq_HU]

Gain-of-function mutant p53 can function through a mutp53-MCM5-Sting-noncanonical NFkB siganling axis. We will analyze the transcriptional profils of head and neck cancer stable cell lines UM-SCC-1 and MDA1586 with overexpression or downregulation of mutant p53 in the presence or absence of Sting or RelB knockdown under the treatment with or without hydroxyurea. Overall design: Total RNA extraction from UM-SCC-1 stable cell lines treated with hydroxyurea were used for RNA-seq.