International Mouse Phenotyping Consortium

The IMPC is a confederation of international mouse phenotyping projects working towards the agreed goals of the consortium: To undertake the phenotyping of 20,000 mouse mutants over a ten year period, providing the first functional annotation of a mammalian genome. Maintain and expand a world-wide consortium of institutions with capacity and expertise to produce germ line transmission of targeted knockout mutations in embryonic stem cells for 20,000 known and predicted mouse genes. Test each mutant mouse line through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease. Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems; Maintain and expand collaborative “networks” with specialist phenotyping consortia or laboratories, providing standardized secondary level phenotyping that enriches the primary dataset, and end-user, project specific tertiary level phenotyping that adds value to the mammalian gene functional annotation and fosters hypothesis driven research; and Provide a centralized data centre and portal for free, unrestricted access to primary and secondary data by the scientific community, promoting sharing of data, genotype-phenotype annotation, standard operating protocols, and the development of open source data analysis tools. Members of the IMPC may include research centers, funding organizations and corporations.

国际小鼠表型学联盟（IMPC）是一个由多个国际小鼠表型学项目组成的联合体，致力于实现联盟达成的共同目标：在十年内对20,000个小鼠突变体进行表型分析，为哺乳动物基因组提供首次功能注释。联盟旨在维护并扩大一个全球性的机构网络，这些机构具备产生胚胎干细胞中靶向敲除突变体遗传传递的能力和专业知识，针对已知的20,000个和预测的小鼠基因。通过广泛的初级表型分析流程，对所有主要成年器官系统和大多数人类重大疾病领域进行每个突变小鼠品系的测试。通过这一活动，并利用数据注释工具，系统地旨在发现并赋予每个基因生物学功能，推动新观点的产生，并为生物系统的研究奠定基础；维护并扩大与专业表型学联盟或实验室的协作“网络”，提供标准化的二级表型分析，以丰富初级数据集，并为终端用户和特定项目提供三级表型分析，增加哺乳动物基因功能注释的价值，并促进以假设驱动的研究；此外，为科学界提供一个中央数据中心和门户，以免费、无限制的方式访问初级和二级数据，促进数据的共享、基因型-表型注释、标准操作规程的开发以及开源数据分析工具的构建。国际小鼠表型学联盟的成员可能包括研究中心、资助组织和公司。