MicroRNAs (miRNAs) act within Argonaute proteins to guide repression of mRNA targets. Although various approaches have provided insight into target recognition, the sparsity of miRNA–target affinity m
Supporting Information. Text S1 provides additional detail about alternative forms of the cis-regulatory expressions, discusses Michaelis-like functions in which there is a leak term and how these are
Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regu
We propose a statistical method to model gene regulation by paired expression and chromatin accessibility (PECA) data, which dissects the regulatory elements (RE) of the genome by modeling their inter
