TABLE 2 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer

The top two significant genes associated with overall survival across nine colorectal cancer relevant signaling pathways for both Black/AA and White cohorts from the TCGA, PanCancer Atlas dataset. A Kaplan–Meier estimate, and log-rank test were used to compute the association between patient overall survival and gene expression and report the associated HR, confidence intervals, P-value, P-adj (P-adjusted value), and SE. “Patients” indicates the number of patients for which data were available. “Significant”, indicates the number of significant genes out of the total number of genes for this pathway. The fold change and P-value cutoff used were 0.5 and 0.05, respectively. The genes in bold were found to be common top significant genes in both Black/AA and White cohorts in the associated STN (Supplementary Table S3)