The Heat Shock response (HSR) is a highly conserved transcriptional program induced by the exposure to a variety of environmental stressors. Following an insult, a small subset of genes, known as the

NIAID Data Ecosystem50

Mammalian Heat Shock Response And Mechanisms Underlying Its Genome-wide Transcriptional Regulation. Mus musculus

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应激反应基因

Heat shock response (HSR) is critical for survival of organisms undergoing proteotoxic stress. Heat shock factor 1 (HSF1) is widely believed to be the master regulator of this response. Here, we exami

NIAID Data Ecosystem30

Genome-wide maps of HSF1 phase separation in heat shock and non-heat shock cells

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相分离

HSF1 binds DNA via the DBD domain, causing gene upregulation during HS. We assessed the effect of RD-mediated phase separation on chromatin targeting of HSF1 using Cut&Tag followed by high-throughput

NIAID Data Ecosystem60

Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response_Chowdhary et al.

活细胞成像分析

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Raw, unprocessed live cell imaging data for the key Figure 1 of the manuscript "Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response" by Chowdhary et al. The

NIAID Data Ecosystem50

Yeast linker histone HHO1p effect on transcription before and after heat shock

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