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Novel Positive cancer rescue mutants by name.

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Figshare2015-12-02 更新2026-05-11 收录
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Mutants are named with the cancer mutation appearing first with capital letters followed by the putative cancer rescue mutation(s) appearing after the underscore. P152L means that the proline at the 152nd amino acid location in p53 is mutated into a leucine. The mutants appearing italicized with a (W), e.g., P152L_k101e, etc., are weak cancer rescue mutants. All others are strong cancer rescue mutants. Artifactual Mutants are cancer rescue mutants that contained more than one cancer rescue mutation or were not in any of the regions, due to background mutagenesis and limitations in early versions of the saturation mutagenesis technique.

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2015-12-02
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