Histopathological changes measured in this study.

a Acanthosis/basal cell hyperplasia: thickening of the prickle layer or increase in basal cell number;b Microabcess: very small circumscribed collection of white blood cells;c Subepidermal clefting: localised or generalised detachment of the epidermis.d Orthohyperkeratosis: thickening of the outermost layer of the epidermis, cells are anucleated;e Para-hyperkeratosis: thickening of the outermost layer of the cells, cells are nucleated.f Each parameter was scored from 0–5, where 0 = within normal limits, 1 = minimal change, 2 = mild change, 3 = moderate change, 4 = severe focal change, 5 = severe extensive changeHistopathological changes measured in this study.