Oxidized Low-Density Lipoprotein drives dysfunction of the liver lymphatic system

Single-cell RNA-sequencing revealed that the transcriptional profile of LECs from HFHC livers was consistent with changes in the LEC transcriptome that reflect both proliferation and a potential de-differentiation of liver LECs in the context of disease which may impact their functions, such as permeability and metabolism. Liver stromal cells were harvested from mice fed either control or high fat, high cholesterol diet, flow sorted to enrich for endothelial cell populations and subjected to single-cell RNA-seq.