Early in vivo genome adaptation of Helicobacter pylori BCS 100 during an experimental human infection study

Using SMRT® sequencing technology, we investigated the degree of genome and methylome evolution of H. pylori re-isolates from the antrum and corpus of 10 infected human volunteers who participated in an experimental human infection study.In addition, Illumina sequencing was performed to examine the variability within 16 colonies from the challenge strain (BCS 100).