Antibacterial and antifungal activity of synthetic arasin 1 and its derivativesa.

aThe values outlined are the MIC and IC50 values for bacteria and fungi, respectively.bMIC was defined as the lowest peptide concentration tested resulting in no visible bacterial growth. Bacteria were tested at 37°C in 50% MH at a concentration of 2.5×105 cells/mL.cIC50 was defined as the lowest concentration tested which yielded less than 50% visible growth compared to the growth control. Fungi were tested in and potato dextrose medium at 20°C, except for C. albicans that was tested at 37°C and at concentrations of 2.5×105 cells/mL. Each data are representative of three individual experiments.dnd: not determined.